proline rich — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2314	PF-431396		FAK , PYK2
	PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).		FAK , PYK2
T6177	PF-562271 besylate	PF-00562271 Besylate	FAK , PYK2 , CDK
	PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, exc...		FAK , PYK2 , CDK
T2465	PF-562271	PF562271,PF 562271	FAK , PYK2 , CDK
	PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).		FAK , PYK2 , CDK
T1918	NVP-TAE 226	TAE226	Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
	NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.		Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
T21768	PF-562271 hydrochloride	PF-562271 HCl	FAK , PYK2 , CDK
	PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other pr...		FAK , PYK2 , CDK
T22397	PF-4618433		Others
	PF-4618433 is a dual inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2).		Others
T80408	Bac7(1-35)
	Bac7(1-35) is a proline-rich antimicrobial peptide that exhibits selective activity against Gram-negative bacteria, functioning intracellularly following membrane translocation [1].
T75870	PR-39 TFA
	PR-39 TFA, a natural peptide rich in proline and arginine with antibacterial properties, acts as a noncompetitive, reversible, and allosteric inhibitor of the proteasome. It specifically attaches to the α7 subunit of the...

Compounds

PF-431396

T2314

Synonym: PF-00562271 Besylate

Target: FAK, PYK2, CDK

PF-562271

T2465

Synonym: PF562271,PF 562271

Target: FAK, PYK2, CDK

NVP-TAE 226

T1918

Synonym: TAE226

Target: Apoptosis, FAK, c-Met/HGFR, PYK2, IGF-1R

PF-562271 hydrochloride

T21768

Synonym: PF-562271 HCl

Target: FAK, PYK2, CDK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03748	BCL2L12 Protein, Human, Recombinant (GST)	Human	E. coli
	BCL2-like 12 (BCL2L12 ) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the predicti...
TMPY-03048	PRAP1 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	PRAP1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 41.4 kDa and the accession number is AAL16670.1.
TMPY-03076	PRAP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	PRAP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.4 kDa and the accession number is AAL16670.1.
TMPY-04623	PRRG2 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	The genes encoding a family of proteins termed proline-rich gamma-carboxyglutamic acid (PRRG) proteins were identified and characterized more than a decade ago. These novel membrane proteins have an extracellular gamma-c...
TMPY-00572	PRELP Protein, Human, Recombinant	Human	HEK293 Cells
	PRELP Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 41.8 kDa and the accession number is P51888.
TMPY-00571	PRELP Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	PRELP Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 68.3 kDa and the accession number is P51888.
TMPH-01605	BAG6 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	BAG6 Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.7 kDa and the accession number is P46379.
TMPH-01606	BAG6 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus Insect Cells
	BAG6 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 38.7 kDa and the accession number is P46379.
TMPH-01255	DNM1L Protein, Human, Recombinant (His & Myc)	Human	E. coli
	DNM1L Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 84.4 kDa and the accession number is O00429.
TMPJ-01277	CRT2 Protein, Human, Recombinant	Human	E. coli
	Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-doma...
TMPY-02319	Galectin-3 Protein, Human, Recombinant	Human	E. coli
	LGALS3 (Galectin 3) is a Protein Coding gene. This gene encodes a member of the galectin family of carbohydrate-binding proteins. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain an...
TMPJ-01259	CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (aa 22-117, hFc)	Cynomolgus	HEK293 Cells
	T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delt...
TMPY-01840	TLT-1/TREML1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusive...